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Stress in early life could lead to major depressive disorder

[Edited By: Admin]

Thursday, 9th May , 2019 04:03 pm

People who take stress in early life are at risk of developing negative thinking which could lead to major depressive disorder (MDD), says a study.

"This study supports a wider body of literature which suggests that depression may develop from an interesting yet complex interaction between biological and psychological processes," said study lead author Emma Robinson, Professor at the University of Bristol in Britain.

Using a rodent model of early life adversity, the study showed that offspring are much more sensitive to negative biases in their cognition when treated with the stress hormone, corticosterone. The research showed a dose of corticosterone had no effect on normal rats but caused a negative bias in the early life adversity animals.

The study also found that the early life adversity rats were less likely to anticipate positive events and failed to properly learn about reward value. These impairments in reward-related cognition are particularly interesting as one of the main features of depression is a loss of interest in previously enjoyable activities.

The researchers suggest that these neuro-psychological effects might explain why early life adversity can make people more likely to develop depression.

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